Gspt1 off target
WebApr 4, 2024 · However, the underlying mechanism remains unclear. To address this research gap, we examined the impact of GSPT1 on cell proliferation, apoptosis, migration, and invasion in vitro as well as tumor growth in vivo in ... The GSPT1/GSK pathway may thus be an effective target for controlling colon cancer. Keywords: GSK-3β pathway; … WebMar 2, 2024 · G1 to S phase transition protein 1 homologue (GSPT1; also known as eRF3a) is a target of thalidomide analogues CC-885 and the related compound CC-90009 and is a translation termination release...
Gspt1 off target
Did you know?
WebCEREP (panel with 44 proteins) tested at 10 µM No off target MRT-2359, a Rationally Designed GSPT1 MGD MRT-2359 is a Selective Inducer of Cereblon Proximity and GSPT1 MGD Representative Viability Curves in NSCLC Lines Real-world molecular and genomic data analyses performed on 3241 lung cancers (in collaboration with Tempus, Inc.) Web100042625 Ensembl ENSG00000084207 n/a UniProt P09211 n/a RefSeq (mRNA) NM_000852 XM_036155425 RefSeq (protein) NP_000843 n/a Location (UCSC) Chr 11: 67.58 – 67.59 Mb n/a PubMed search Wikidata …
WebMar 28, 2024 · GSPT1 is a protein involved in the termination of translation, SALL4 is a transcription factor often over-expressed in HCC patients and correlating with poor prognosis, and NEK7 is a protein in... WebFeb 5, 2024 · Off-target effects can also arise from the binary engagement of the target binding ligand of the PROTAC to other proteins in the same way as the POI. ... (IKZF1 …
WebMar 15, 2024 · In cancer cells, one of the genes is inactivated by a mutation; the other will be switched off by a drug. Known as molecular glues, Monte Rosa’s treatments are small molecules designed to treat disease by commandeering the body’s own protein-degrading processes. ... GSPT1, the target of Monte Rosa’s lead program, isn’t druggable by more ... WebMar 2, 2024 · G1 to S phase transition protein 1 homologue (GSPT1; also known as eRF3a) is a target of thalidomide analogues CC-885 and the …
WebSep 30, 2024 · The basal equivalent current (Ieq) was also reduced in treated cells, indicating reduced sodium absorption at baseline. GSPT1 is the only reported target of CC-90009 . Thus, ENaC or a regulator of ENaC represents a previously undescribed off-target effect of the compound. smith motor sales of haverhill incWebAug 15, 2024 · Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against … river 8 a 0WebFeb 4, 2024 · Loss of GSPT1 in AML cells triggers the ISR via ATF4, culminating in cell death. These events are opposed by loss of the alternative splicing modulators … rivera 68 deluxe with stage 2 modificationsWebAug 20, 2024 · GSPT1 (G1 to S phase transition 1) is a translation termination factor that recognizes the termination codon by binding eRF1, forcing the proteins to dissociate from the ribosome after... river949 towersWebSep 30, 2024 · The basal equivalent current (Ieq) was also reduced in treated cells, indicating reduced sodium absorption at baseline. GSPT1 is the only reported target of … river 7 factsWeb4 Disease Target Structure Research Center, ... Compound 34f effectively induced GSPT1 degradation with a DC 50 of 0.269 nM and Dmax of >95 % at 10 nM concentration in KG-1 cells. An in vivo xenograft study showed that compound 34f effectively suppressed TMD8-driven tumor growth, suggesting a potential role in the development of novel GSPT1 ... smith motors hattiesburg boatsWebDec 1, 2024 · Translation termination factor GSPT1 is a phenotypically relevant off-target of heterobifunctional phthalimide degraders. ACS Chem Biol, 13 (3) (2024), pp. 553-560. CrossRef View in Scopus Google Scholar [55] C.E. Powell, et al. Selective degradation of GSPT1 by cereblon modulators identified via a focused combinatorial library. smith motor sales lafayette tn